Endothelin receptors in GtoPdb v.2023.1
نویسندگان
چکیده
Endothelin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Receptors [24]) are activated endogenous 21 amino-acid peptides endothelins 1-3 (endothelin-1, endothelin-2 and endothelin-3).
منابع مشابه
Contractile endothelin-B (ETB) receptors
Contractile endothelin-B (ETB) receptors in human small bronchi. M. Adner, L.O. Cardell, T. Sjöberg, A. Ottosson, L. Edvinsson. ERS Journals Ltd 1996. ABSTRACT: Endothelins (ETs) are a family of novel regulatory peptides and various lines of evidence suggest an important role for ETs in regulating pulmonary function. Two receptors for endothelin, ETA and ETB, have been found in the human lung,...
متن کاملEndothelin Receptors and Their Antagonists☆☆☆
All three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are expressed in the human kidney, with ET-1 being the predominant isoform. ET-1 and ET-2 bind to two G-protein-coupled receptors, ETA and ETB, whereas at physiological concentrations ET-3 has little affinity for the ET(A) receptor. The human kidney is unusual among the peripheral organs in expressing a high dens...
متن کاملGene expression of endothelin-1, endothelin-converting enzyme-1, and endothelin receptors in human epididymis.
We have previously reported the presence of endothelin-1 (ET-1) and its receptors in the human testis. In the present study we extended our investigations to human epididymis. The rationale of our study originated from the fact that sperm appear to be immotile during their transit through the epididymis. Hence, it is conceivable that specific factors, unknown to date, are present in this organ,...
متن کاملExpression of endothelin-1, endothelin-converting enzyme, and endothelin receptors in chronic heart failure.
BACKGROUND Elevated plasma levels of endothelin (ET)-1 have been reported in association with heart diseases, including heart failure. Furthermore, it has been suggested that ET-1 acts as a local autocrine/paracrine factor with biological activities such as vasoconstriction, mitogenesis, and inotropic effects on the heart. This study investigated alterations of ET-1, ET receptor, and endothelin...
متن کاملEndothelin peptides and receptors in human kidney.
1. Animal kidneys are exquisitely sensitive to the vasoconstrictor and antinatriuretic effects of the endogenous vascular peptide endothelin. Animal studies have implicated endothelin in cyclosporin A and ischaemia-mediated renal damage. 2. In man, endothelin levels are raised in various disorders. Orally active endothelin antagonists are now being developed, but little was known of endothelin'...
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ژورنال
عنوان ژورنال: IUPHAR/BPS guide to pharmacology CITE
سال: 2023
ISSN: ['2633-1020']
DOI: https://doi.org/10.2218/gtopdb/f21/2023.1